Modest-molecule inhibitors with the serine dipeptidases DPP8 and DPP9 (DPP8/nine) induce a lytic method of cell Loss of life named pyroptosis in mouse and human monocytes and macrophages1,two. In mouse myeloid cells, Dpp8/9 inhibition activates the inflammasome sensor Nlrp1b, which in turn activates
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